Drug Repositioning in the Mirror of Patenting: Surveying and Mining Uncharted Territory
نویسنده
چکیده
Drug repositioning—the investigation, development and use of active pharmaceutical ingredients for a therapeutic class that is different from the original one—is much more than a “recycling” of known drugs or drug candidates (Oprea and Mestres, 2012). Quite the opposite, it creates novel insights that are of additional scientific and public health interest. Exploiting the fact that very few compounds act on only one molecular target is just one aspect; drug repositioning can also use drug targets as a starting point to screen compound libraries. Nowadays it goes far beyond serendipity, making use of the newest insights in chemical genomics (Bisson, 2012), computational biology (Hodos et al., 2016; Li et al., 2016), systems medicine (Mei et al., 2016), and text mining (Tari and Patel, 2014) to utilize pharmacological activities (known or newly identified) in more ways than had been originally envisaged. This approach extends to biotechnology products, and even vaccines (Veljkovic and Paessler, 2016). The constantly growing number of repositioning-related peer review papers in PubMed reflects the growing scientific interest in the subject. For 2016, a search for papers indexed under the MeSH term “drug repositioning” or the keyword “drug repurposing” returned 306 hits. Considering that many relevant contributions are not being indexed in this way, and do not contain “drug repurposing” in their titles or abstracts, this captures only part of the actual publishing activity even as reflected in PubMed-listed journals.
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2017